A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

September 9, 2026 · 12:00 am 1 sources

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• A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion
  Nature · September 9, 2026 00:00
  Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8 SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.