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Science

A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation

September 30, 2026 · 12:00 am 1 sources

Image: Nature

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  • A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation
    Nature · September 30, 2026 00:00
    Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3 Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in…

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