An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors

October 28, 2026 · 12:00 am 1 sources

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• An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors
  Nature · October 28, 2026 00:00
  Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03288-5 A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off a protein-degradation…