De novo design of cysteine proteases

October 14, 2026 · 12:00 am 2 sources

Image: Nature

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Wires & papers of record

• De novo design of cysteine proteases
  Nature · October 14, 2026 00:00
  Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.
• Computational design of metalloproteases
  Nature · October 14, 2026 00:00
  Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2 RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications…