Modelling mouse embryogenesis from chemically induced totipotent stem cells

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Wires & papers of record
- Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11164-5 A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation, haematopoiesis and early organogenesis.
- Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11159-2 Long-term live imaging of adult mouse ear skin reveals sex-specific differences in the clonal dynamics of epidermal stem cells and transit-amplifying cells during homeostasis.
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- Scientists have succeeded in reconstructing the family tree of cells in a developing mouse embryo. They recorded cells' relationships, starting when the fertilized egg first split in two and ending after the body and its organs took shape. That period lasted 13.5 days. (Full gestation in mice is…