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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

October 14, 2026 · 12:00 am 1 sources

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  • Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
    Nature · October 14, 2026 00:00
    Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1 A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.

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