Genetic variants that alter gene regulation in specific cell types are closely tied to disease

October 28, 2026 · 12:00 am 4 sources

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Wires & papers of record

• Genetic variants that alter gene regulation in specific cell types are closely tied to disease
  Nature · October 28, 2026 00:00
  Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03067-2 Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health.
• Tandem repeat variation shapes immune cell type-specific gene expression
  Nature · October 28, 2026 00:00
  Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-10438-2 Whole-genome sequencing and cell-level gene expression measurements show that length variation in tandem repeats in the human genome contributes to cell type-specific differences in gene regulation and expression, as well as…
• Rare and common genetic variants shape single-cell immune gene expression
  Nature · October 28, 2026 00:00
  Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-10721-2 Phase 1 of TenK10K takes single-cell RNA sequencing and matched whole-genome sequencing data from 1,925 individuals, enabling detection of associations for common and rare genetic variants, the latter of which have been…
• Genetic variants shape single-cell chromatin accessibility and disease risk
  Nature · October 28, 2026 00:00
  Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11173-4 Single-cell chromatin accessibility profiling identifies cell-type-specific and cell-state-specific genetic effects that link non-coding variants to immune disease risk.