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Science

GRP75-dependent SIMPA mediates inter-organellar quality control

October 21, 2026 · 12:00 am 1 sources

Image: Nature

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  • GRP75-dependent SIMPA mediates inter-organellar quality control
    Nature · October 21, 2026 00:00
    Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and…

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