Harmful tau spreads like self-propagating prion proteins

September 30, 2026 · 12:00 am 2 sources

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Wires & papers of record

• Harmful tau spreads like self-propagating prion proteins
  Nature · September 30, 2026 00:00
  Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02778-w Structural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau.
• Prion-like transmission of human tau strains in the mouse brain
  Nature · September 30, 2026 00:00
  Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11061-x Mouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting strain-specific tau propagation and disease modelling.