MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

October 28, 2026 · 12:00 am 1 sources

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• MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
  Nature · October 28, 2026 00:00
  Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3 In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac…