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Science

Predicting genome-wide functional constraints with GPN-Star

September 9, 2026 · 12:00 am 1 sources

Image: Nature

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  • Predicting genome-wide functional constraints with GPN-Star
    Nature · September 9, 2026 00:00
    Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11005-5 GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species.

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