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Science

T and B cells recognize splicing-derived neutrophil neoantigens in lupus

October 28, 2026 · 12:00 am 1 sources

Image: Nature

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  • T and B cells recognize splicing-derived neutrophil neoantigens in lupus
    Nature · October 28, 2026 00:00
    Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11219-7 In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing…

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