This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?

November 3, 2026 · 12:00 am 1 sources

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• This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?
  Nature · November 3, 2026 00:00
  Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03504-2 Physicians were excited about several therapies that slash levels of lipoprotein(a) — an important cardiovascular risk factor. One major trial failed to show a benefit, and now scientists are scrambling to work out what…