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Science

TRI-611, a selective, brain-penetrant molecular glue degrader of ALK

September 9, 2026 · 12:00 am 1 sources

Image: Nature

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  • TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
    Nature · September 9, 2026 00:00
    Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3 TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive…

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