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Science

WEE1 opposes APC/C CDH1 activity to promote S phase entry

October 21, 2026 · 12:00 am 1 sources

Image: Nature

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  • WEE1 opposes APC/C CDH1 activity to promote S phase entry
    Nature · October 21, 2026 00:00
    Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-x Experimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

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